01 · Scientific Reports 12, controlled comparison, 2022
Menopause and the skin's ceramides
- What was tested
- Whether the epidermal changes of menopause show up in the lipids that hold water in the outer layer of skin, and whether hormone therapy changes that.
- How
- Pre-menopausal women, post-menopausal women and post-menopausal women taking hormone therapy had hormone levels measured, water loss through the skin assessed, and stratum corneum lipids sampled from skin that sun never reaches. Keratinocytes were also treated with oestradiol in the laboratory.
- What was found
- Post-menopausal skin held fewer ceramides, and shorter ones. The hormone therapy group did not show the change. Oestradiol in the blood tracked with ceramide abundance, and oestradiol raised ceramide production in the cells.
- What it means for you
- The dryness underneath the itch is not vague ageing. It is a specific, measurable loss in the layer that holds water, tied to oestrogen.
